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Updated: Jan 3, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
[Progress of human CCAAT/enhancer binding protein epsilon on inflammation and infection]
Yajun Liu1, Tao Chen1, Huaping Liang2
1Department of Intensive Care Unit, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou, China.
Objective:
Inflammation and infection are main causes of death in critically ill patients. But traditional treatment are non-comprehensive and limited. Human CCAAT/enhancer binding protein epsilon (C/EBPε) is a key transcription factor regulating the terminal differentiation of neutrophils. It plays an important role in anti-inflammatory and anti-infective process by regulating inflammatory response cells. This article reviews the changes of C/EBPε in inflammation and infection, related regulatory mechanisms and targeted reversal measures, in order to provide references for exploring new directions and effective measures for inflammation and infection treatment.
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