Related Experiment Video
Updated: Jan 3, 2026
Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
Published on: January 22, 2020
Hollow molecularly imprinted polymer based quartz crystal microbalance sensor for rapid detection of methimazole in
Xiaolei Zhao1, Yu He1, Yanan Wang1
1State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science & Technology, 29 The Thirteenth Road, Tianjin Economy and Technology Development Area, Tianjin 300457, PR China.
Abstract:
In this study, a novel detection method of methimazole was proposed based on the hollow molecularly imprinted quartz crystal microbalance (QCM) sensor, in which the hollow imprinted polymers (H-MIPs) were firstly prepared through the surface imprinted techniques, using hollow silica spheres as matrix supporting material and methimazole as template molecule. The characterizations of H-MIPs were carefully studied. Compared with traditional MIPs, H-MIPs exhibited faster mass transfer rate and higher adsorption capacity. After coating onto the surface of Au chip, the H-MIPs QCM sensor was fabricated. Based on the frequency shift, good linear behavior in the range of 5-70 μg L-1, limit of detection of 3 μg L-1, and good recoveries of 88.32%-107.96% in the spiked pork, beef and milk were obtained. The analysis process could complete within 8 min. The developed sensor provided an effective, fast and accurate method for the methimazole detection in food samples.
