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Association of Baseline Smoking Status with Long-Term Prognosis in Patients Who Underwent Percutaneous Coronary

Ru Liu1, Zhan Gao1, Huanhuan Wang1

  • 1Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Journal of Interventional Cardiology
|November 28, 2019
PubMed

Insights

In coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI), baseline smoking status did not significantly impact long-term prognosis. Risks for major adverse coronary events, including death and stroke, were similar between current smokers and nonsmokers after two years.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Public Health

Background:

  • Limited data exists on the "smoker's paradox" in Chinese populations with coronary artery disease (CAD).
  • Understanding the impact of baseline smoking status on long-term prognosis after percutaneous coronary intervention (PCI) is crucial.

Purpose of the Study:

  • To analyze the association between baseline smoking status and the long-term prognosis of CAD patients who have undergone PCI.
  • To investigate the presence of the "smoker's paradox" in a large Chinese cohort.

Main Methods:

  • A cohort of 10,724 consecutive patients undergoing PCI between January and December 2013 was analyzed.
  • Two-year clinical outcomes, including major adverse coronary events (MACE) such as all-cause death, revascularization, myocardial infarction (MI), and stroke, were compared between current smokers and nonsmokers.

Main Results:

  • Current smokers (57.1%) were younger, predominantly male, and had fewer comorbidities than nonsmokers (42.9%).
  • No significant difference was observed in 2-year all-cause death rates between groups.
  • Nonsmokers had higher rates of stroke and bleeding, while current smokers had a higher rate of revascularization; however, multivariable analysis showed no independent association of smoking with any endpoint.

Conclusions:

  • Baseline smoking status did not independently predict 2-year outcomes in CAD patients after PCI.
  • Risks for all-cause death, MACE, MI, revascularization, stroke, and bleeding were similar between current smokers and nonsmokers.
  • The study suggests that the "smoker's paradox" may not be a significant factor in this Chinese population undergoing PCI.
Abstract

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