Related Experiment Video
Updated: Jan 3, 2026

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
MGUS bone
Osamu Imataki1, Makiko Uemura1
1Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Abstract:
A 65-year-old man was referred to our hospital to undergo orthopedic surgery due to severe cervical ossification of the posterior longitudinal ligament. Computed tomography scanning showed a massive osteolytic lesion in his pelvis. Other screening examinations including detection of bone mineral density and osteoporosis biomarkers, bone scintigram and 18F-fluorodeoxyglucose-positron emission tomography were all normal. Bone marrow aspiration revealed slightly increased plasmacytes at 3.8%. These findings led to a diagnosis of monoclonal gammopathy with undetermined significance (MGUS). Architectural osteolytic bone associated with MGUS without apparent abnormality in bone mineral metabolism could be a common occurrence prior to onset or occurrence of multiple myeloma.
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