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ANGPTL4: A Predictive Marker for Diabetic Nephropathy.

Eman Al Shawaf¹, Mohamed Abu-Farha¹, Sriraman Devarajan²

¹Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait.

Journal of Diabetes Research

|November 28, 2019

Summary

Circulating ANGPTL4 levels are elevated in patients with diabetic nephropathy (DN), correlating with kidney function markers and other proteins. This suggests ANGPTL4 may serve as a biomarker for detecting diabetic kidney disease in type 2 diabetes patients.

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Area of Science:

Endocrinology
Nephrology
Metabolic Research

Background:

Angiopoietin-like 4 (ANGPTL4) regulates triglyceride metabolism and is implicated in hypertriglyceridemia and nephrotic syndrome.
Previous research suggests a link between ANGPTL4, hypertriglyceridemia, and albuminuria in nephrotic syndrome.
This study investigates ANGPTL4 levels in diabetic nephropathy (DN) and its association with key DN-related proteins.

Purpose of the Study:

To quantify circulating ANGPTL4 levels in individuals with and without diabetic nephropathy (DN).
To examine the association between ANGPTL4 and established DN-associated proteins, specifically IGFBP1 and IGFBP4.
To explore the potential of ANGPTL4 as a biomarker for diabetic kidney disease.

Main Methods:

A multiplexing assay was used to measure ANGPTL4, IGFBP1, IGFBP3, and IGFBP4 in fasting plasma samples.
The study included 122 Kuwaiti participants: 36 controls, 37 individuals with type 2 diabetes (T2D) and normal kidney function, and 49 individuals with T2D and DN.
Clinical parameters such as albumin-to-creatinine ratio (ACR), serum creatinine, and estimated glomerular filtration rate (eGFR) were assessed.

Main Results:

ANGPTL4 levels were significantly higher in patients with DN compared to controls.
Elevated ANGPTL4 showed significant correlations with DN clinical markers: ACR, serum creatinine, and eGFR.
ANGPTL4 levels positively correlated with IGFBP1 and IGFBP4, with IGFBP1 and triglycerides identified as predictors of higher ANGPTL4 in DN patients.

Conclusions:

Circulating ANGPTL4, IGFBP1, and IGFBP4 are significantly elevated in patients with DN.
The correlation of ANGPTL4 with DN markers and other proteins suggests its involvement in the disease pathogenesis.
ANGPTL4 shows promise as a potential biochemical marker for detecting diabetic kidney disease in individuals with T2D.