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Updated: Jan 3, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Lung Cancer in the Young.

Marco Galvez-Nino¹, Rossana Ruiz², Joseph A Pinto³

¹Medical Oncology Department, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru. marco.galveznino@gmail.com.

|November 28, 2019

Summary

Lung cancer in individuals 40 or younger is rare but distinct, often presenting as advanced adenocarcinoma in women with poor survival outcomes. This study highlights a higher incidence in Peru compared to global data.

Keywords:

Clinic-pathological Incidence Lung cancer Survival Young

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Area of Science:

Oncology
Epidemiology

Background:

Lung cancer median age at diagnosis is 70 years.
Lung cancer in patients 40 or younger is uncommon and may represent a distinct disease entity.
Limited studies exist on the clinic-pathological characteristics of lung cancer in young patients.

Purpose of the Study:

To describe the incidence and characteristics of lung cancer in patients aged 40 or younger at a tertiary cancer center in Lima, Peru.
To evaluate the clinic-pathological features of non-small cell lung cancer (NSCLC) in this young population.

Main Methods:

Retrospective analysis of lung cancer patients diagnosed between 2009 and 2017 at the Instituto Nacional de Enfermedades Neoplasicas (INEN).
Data collected from clinical files included epidemiologic and clinic-pathological information.
Statistical analysis performed using SPSS software.

Main Results:

Out of 3823 lung cancer patients, 166 (4.3%) were 40 years or younger.
The majority (82.5%) of young patients had NSCLC, with a median age of 36 years.
Common symptoms included cough, chest pain, and dyspnea. Adenocarcinoma was the predominant type (63.3%), with 84.7% diagnosed at advanced stages. Median overall survival was 8.2 months.
A smoking history was present in only 14.4% of patients, and 59.1% were female.

Conclusions:

The proportion of young lung cancer patients in this Peruvian cohort is higher than reported in international literature.
Lung cancer in young individuals is often sporadic, more prevalent in women, typically adenocarcinoma, and diagnosed at advanced stages, leading to poor survival.
These findings suggest lung cancer in the young may differ significantly from that in older populations.