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Published on: July 20, 2022
Left atrial strain in left ventricular diastolic dysfunction: have we finally found the missing piece of the puzzle?
Giulia Elena Mandoli1, Nicolò Sisti2, Sergio Mondillo1
1Department of Cardiovascular Diseases, University of Siena, Siena, Italy.
Insights
Left atrial longitudinal strain measured by speckle tracking echocardiography offers a sensitive method to assess diastolic dysfunction and guide heart failure management. This technique improves upon traditional echocardiography, especially for heart failure with preserved ejection fraction.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Background:
- Echocardiography is crucial for evaluating diastolic function and left ventricular filling pressures in heart failure (HF) patients.
- Current algorithms for diastolic dysfunction (DD) grading have limitations, including a "gray zone".
- The rising incidence of heart failure with preserved ejection fraction (HFpEF) necessitates more sensitive diagnostic tools.
Purpose of the Study:
- To review the evidence for left atrial (LA) longitudinal strain using speckle tracking echocardiography (STE).
- To explore LA strain's role in assessing diastolic function and HFpEF.
- To evaluate LA strain as a diagnostic and therapeutic management parameter.
Main Methods:
- Utilizing speckle tracking echocardiography (STE) to measure left atrial (LA) longitudinal strain.
- Analyzing LA strain's angle-independent and reproducible measurement capabilities.
- Reviewing current literature on LA strain in diastolic dysfunction and HFpEF assessment.
Main Results:
- Left atrial (LA) longitudinal strain demonstrates high specificity and sensitivity for diastolic dysfunction (DD) assessment.
- LA strain overcomes limitations of Doppler-based echocardiography.
- LA strain provides reproducible measures of left atrial (LA) deformation, crucial for left ventricular (LV) function.
Conclusions:
- Left atrial (LA) longitudinal strain is a valuable parameter for evaluating diastolic function and guiding HFpEF management.
- LA strain can be used within standard echocardiographic algorithms or as a standalone diagnostic tool.
- This technique enhances the noninvasive assessment of diastolic function, improving patient care.
Abstract:
The noninvasive estimation of diastolic function with echocardiography as a surrogate of left ventricular filling pressure is considered an essential step in the clinical evaluation of patients with conditions predisposing to heart failure (HF). Latest algorithms for the assessment of diastolic dysfunction (DD) lay on several 2D standard parameters and describe a precise grading to quantify its severity. The persistence of a "gray zone" of values in which DD quantification is not possible, together with an epidemiological increase of conditions predisposing to heart failure with preserved ejection fraction (HFpEF), has led to the search and use of parameters with higher specificity and sensitivity: one of these is left atrial (LA) longitudinal strain in the frame of speckle tracking echocardiography (STE). LA anatomy and mechanics are crucial for preserving left ventricular (LV) function and asymptomatic condition of the patient. LA longitudinal strain is angle-independent, thus overcoming Doppler limitations, and provides reproducible measures of LA deformation. This review examines the latest evidences concerning the use of LA longitudinal strain in the assessment of diastolic function and HFpEF, with a particular focus on its role in standard echocardiographic algorithms or as a lone parameter to guide diagnosis and therapeutic management.
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