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A tumor suppressor DLC1: The functions and signal pathways

Yang Zhang1, Guorong Li1

  • 1Shandong Provincial Key Laboratory of Animal Resistant, School of Life Sciences, Shandong Normal University, Jinan, China.

Journal of Cellular Physiology
|November 28, 2019
PubMed

Insights

Deleted in liver cancer-1 (DLC1) suppresses tumors by regulating cell signaling. Downregulation of DLC1 promotes cancer progression, but natural products may restore its expression to inhibit cancer growth.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Deleted in liver cancer-1 (DLC1) is a tumor suppressor gene.
  • DLC1 functions as a GTPase-activating protein for Rho family proteins.
  • Reduced DLC1 expression is observed in many human cancers, correlating with tumor proliferation and metastasis.

Purpose of the Study:

  • To review the characteristics of DLC1 and its family members.
  • To delineate signaling pathways regulated by DLC1 in cancer.
  • To explore clinical data and natural product-mediated upregulation of DLC1 for cancer inhibition.

Main Methods:

  • Literature review of DLC1 family characteristics.
  • Analysis of signaling pathways involving DLC1.
  • Examination of clinical data and natural product interactions with DLC1.

Main Results:

  • DLC1 regulates critical cancer cell processes including growth, colony formation, apoptosis, senescence, autophagy, migration, and invasion.
  • Clinical data indicates the significance of DLC1 in various cancers.
  • Natural products show potential in upregulating DLC1 expression to inhibit cancer.

Conclusions:

  • DLC1 plays a crucial role in suppressing cancer through diverse cellular mechanisms.
  • Further research is needed to fully elucidate the mechanisms of DLC1-mediated cancer suppression.
Keywords:
DLC1apoptosismigrationproliferationtumor suppressor

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