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A tumor suppressor DLC1: The functions and signal pathways
1Shandong Provincial Key Laboratory of Animal Resistant, School of Life Sciences, Shandong Normal University, Jinan, China.
Journal of Cellular Physiology
|November 28, 2019
Summary
Deleted in liver cancer-1 (DLC1) suppresses tumors by regulating cell signaling. Downregulation of DLC1 promotes cancer progression, but natural products may restore its expression to inhibit cancer growth.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Deleted in liver cancer-1 (DLC1) is a tumor suppressor gene.
- DLC1 functions as a GTPase-activating protein for Rho family proteins.
- Reduced DLC1 expression is observed in many human cancers, correlating with tumor proliferation and metastasis.
Purpose of the Study:
- To review the characteristics of DLC1 and its family members.
- To delineate signaling pathways regulated by DLC1 in cancer.
- To explore clinical data and natural product-mediated upregulation of DLC1 for cancer inhibition.
Main Methods:
- Literature review of DLC1 family characteristics.
- Analysis of signaling pathways involving DLC1.
- Examination of clinical data and natural product interactions with DLC1.
Main Results:
- DLC1 regulates critical cancer cell processes including growth, colony formation, apoptosis, senescence, autophagy, migration, and invasion.
- Clinical data indicates the significance of DLC1 in various cancers.
- Natural products show potential in upregulating DLC1 expression to inhibit cancer.
Conclusions:
- DLC1 plays a crucial role in suppressing cancer through diverse cellular mechanisms.
- Further research is needed to fully elucidate the mechanisms of DLC1-mediated cancer suppression.
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