Keratometric indices for detecting the type of keratoconus: a combined discriminant analysis

This study sought to determine the diagnostic ability of anterior, posterior and total keratometric indices in discriminating keratoconus (KCN) stages 1 to 4 from normal corneas.

Anterior and posterior simulated keratometry (sim-Ksteep and sim-Kflat), maximum keratometry (Kmax), Kmax y co-ordinate, anterior and posterior radii of curvature centred on the thinnest point (ARC-3 mm and PRC-3 mm), and anterior, posterior, and total asphericity (Q-value) measured by Pentacam were extracted from electronic medical records of 200 KCN and 200 normal cases. Stepwise leave-one-out cross-validation and areas under receiver operating characteristic curves (AUROC) were used to detect the best set of indices for differentiating normal from low-grade (stages 1-2, Kmax ≤ 53.00 D) and high-grade (stages 3-4, Kmax > 53.00 D) KCN.

Mean age in KCN and normal groups was 33.10 ± 7.48 and 32.24 ± 9.00 years (p = 0.332), respectively. In the low-grade KCN group, PRC-3 mm (AUROC = 0.986), Kmax (AUROC = 0.979), and Kmax y co-ordinate (AUROC = 0.824) performed best, and the difference in AUROC between PRC-3 mm and Kmax was not significant (p = 0.153). In the high-grade KCN group, Kmax (AUROC = 1.000), PRC-3 mm (AUROC = 0.998), posterior Ksteep (AUROC = 0.970), posterior Q-value (AUROC = 0.940), and posterior Kflat (AUROC = 0.894) performed best, and there was no significant difference in AUROC values between Kmax and PRC-3 mm (p = 0.307) or between posterior Ksteep and posterior Q-value (p = 0.113).

Among the studied keratometric indices, PRC-3 mm and Kmax appear to have the best ability for detecting mild to severe KCN. The next best factors which showed good discrimination ability were Kmax y co-ordinate in low-grade cases and posterior Ksteep and Q-value in high-grade cases.