Related Experiment Videos
The fragile X syndrome: variability of expression in carrier females
P N Howard-Peebles1, W T Brown
1Department of Pathology, U. Texas Health Science Center at Dallas.
American Journal of Medical Genetics
|May 1, 1988
Abstract:
The fra(X) expression in heterozygotes varies considerably from family to family. In family D23, 5 carriers express the fra(X) regardless of age. DNA studies using 3 markers were inconclusive as to whether cytogenetic testing is more reliable in this family than in others. III-2 and III-5 are the critical individuals in the pedigree; further study with closer probes should resolve this question.