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Updated: Jan 3, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of
Sinenhlanhla N Mthembu1,2, Anamika Sharma1,2, Fernando Albericio1,3,4
1Peptide Science Laboratory, School of Chemistry and Physics , University of KwaZulu-Natal , Durban 4001 , South Africa.
Abstract:
Disulfide-reducing agents play a crucial role in bioconjugate chemistry. Herein, we describe the synthesis of a new disulfide-reducing agent [2-(dibenzylamino)butane-1,4-dithiol (DABDT)] that is conveniently prepared from inexpensive aspartic acid. Being nonmalodorous and highly soluble in a broad range of solvents, DABDT is user-friendly. We have demonstrated its performance both in solution and in the solid phase.
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