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Fragile X expression in Martin-Bell syndrome, intellectually normal individuals, and neoplasia, interpreted by a
1B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Petah-Tikva, Israel.
American Journal of Medical Genetics
|May 1, 1988
Abstract:
We present data on fragile X expression in lymphocytes obtained from the following patients: a university student, an infertile couple, 6 of 22 prostatic cancer patients, a meningioma patient, and members of families with meningioma and familial gliomas. All patients were of normal intelligence. In addition, we report 3 cases of central nervous system (CNS) tumors in more typical fragile X families. We suggest that the fragile X expression as well as the clinical findings may be caused by a viral (or similar) infection. The virus may require a receptor protein coded by one allele of a gene on the X chromosome.