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Serum Asprosin Concentrations Are Increased and Associated with Insulin Resistance in Children with Obesity

Min Wang1, Chunyan Yin1, Ling Wang1

  • 1Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Annals of Nutrition & Metabolism
|November 28, 2019
PubMed

Insights

Asprosin levels are higher in obese children and linked to insulin resistance. This peptide may serve as a new marker for predicting advanced obesity-related conditions in pediatric populations.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Research
  • Adipokine Signaling

Background:

  • Asprosin, a newly identified adipokine, plays a role in obesity in adults and animals.
  • Its function and relevance in pediatric obesity remain largely unexplored.

Purpose of the Study:

  • To investigate the role of asprosin in children with obesity.
  • To examine the association between asprosin and key obesity-related markers in this demographic.

Main Methods:

  • A cross-sectional study involving 119 Chinese children (79 obese, 40 lean controls).
  • Measurement of anthropometric data, clinical information, and serum levels of asprosin, TNF-α, adiponectin, and leptin.

Main Results:

  • Serum asprosin concentrations were significantly elevated in obese children compared to lean controls.
  • Higher asprosin levels were observed in children with insulin resistance (IR).
  • Asprosin showed positive correlations with waist-to-hip ratio (WHR), diastolic blood pressure, HOMA-IR, leptin-to-adiponectin ratio, and TNF-α.

Conclusions:

  • Elevated circulating asprosin levels in obese children are associated with insulin resistance.
  • Asprosin may represent a novel biomarker for predicting the progression of pediatric obesity and related metabolic complications.
Abstract

Keywords:
AsprosinChildhood obesityInsulin resistance

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