Immune stromal features in cervical squamous cell carcinoma are prognostic factors for distant metastasis: A...

Malignant tumors are complex structures that must interact with the surrounding environment for growth and invasiveness. This study aimed to comprehensively catalogue the features of immune cell stromal infiltrates within tumor tissue and peri-tumoral tissue and to determine whether these features have prognostic value in cervical squamous cell carcinoma (CxSCC).

Immune stromal features in primary tumors in 122 patients enriched for CxSCC were histologically and immunohistochemically characterized.

Distant metastasis was positively correlated with tumor-node-metastasis (TNM) stage (P <  0.001), lymph-vascular invasion (LVI) (P <  0.001), lymph node metastasis (LNM) (P <  0.001), and tumor budding (P =  0.012). Distant metastasis was also associated with the eosinophil infiltration (P =  0.006); Stromal, intratumoral, invasive-margin, squamous intraepithelial lesion (SIL), and perivascular tumor-infiltrating lymphocytes (TILs); CD68+, CD163+, and CD204+ macrophage infiltration. Multivariate proportional hazard regression analyses revealed that LVI; TNM stage; lymph node metastasis; tumor budding; eosinophil infiltration; CD163+ macrophage infiltration; and stromal and intratumoral TILs were independent predictors of poor DMFS in patients with CxSCC.

Primary tumor immune stromal features can be useful in predicting distant metastasis in CxSCC.