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Updated: Jan 3, 2026

The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy
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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy

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Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia

Shu-Ching Huang1, Jia Y Liang2, Long V Vu2

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.

The Journal of Biological Chemistry
|November 29, 2019
PubMed
Summary

Specific epithelial Protein 4.1R isoforms (4.1R+17b) are crucial for adherens junction (AJ) assembly and stability. These isoforms link the AJ complex to the actin cytoskeleton, regulating epithelial integrity and remodeling.

Keywords:
actinadherens junctionalternative splicingcadherincatenincellular remodelingcytoskeletonepithelial cellprotein 4.1Rspectrin

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