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A National Approach to Pediatric Sepsis Surveillance.

Heather E Hsu1, Francisca Abanyie2, Michael S D Agus3

  • 1Department of Pediatrics, School of Medicine, Boston University and Boston Medical Center, Boston, Massachusetts; heather.hsu@bmc.org.

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Developing effective surveillance for pediatric sepsis is crucial. This study outlines challenges and proposes a preliminary definition for electronic health record-based surveillance to track sepsis in children.

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Area of Science:

  • Public Health
  • Pediatrics
  • Health Informatics

Background:

  • Pediatric sepsis is a significant public health issue requiring improved surveillance.
  • Electronic Health Records (EHRs) offer a valuable resource for population-level sepsis surveillance.
  • Previous work established an EHR-based adult sepsis event definition.

Purpose of the Study:

  • To adapt EHR-based sepsis surveillance methods for pediatric populations.
  • To address unique challenges in pediatric sepsis surveillance.
  • To propose a preliminary pediatric sepsis event definition for validation.

Main Methods:

  • Convening a multidisciplinary pediatric working group.
  • Identifying age-dependent physiological differences and evolving clinical definitions.
  • Developing EHR markers for infection and organ dysfunction in children.
  • Considering children with medical complexity and care regionalization.

Main Results:

  • Challenges specific to pediatric sepsis surveillance were identified.
  • A preliminary pediatric sepsis event surveillance definition was proposed.
  • Next steps for refining and validating the definition were outlined.

Conclusions:

  • Developing a standardized EHR-based surveillance definition is essential for understanding pediatric sepsis burden.
  • This work lays the foundation for national and site-specific pediatric sepsis surveillance.
  • Further validation is needed to implement this tool for improved sepsis care in children.