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Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes

Cristina López-Tinoco1, José Luis Jiménez-Blázquez2, Laura Larrán-Escandón3

  • 1Department of Endocrinology, Puerta del Mar Hospital Cádiz/ Department of Medicine, University of Cádiz, Av. Ana de Viya 21 CP:11009 Cádiz/Dr. Marañón, 3 CP: 11002, Cádiz, Spain. cristinalopeztinoco@gmail.com.

Scientific Reports
|November 29, 2019
PubMed

To evaluate the effectiveness of the different insulin therapies on obstetrics-fetal outcomes in women with pregestational diabetes mellitus. We enrolled 147 pregnant women with pre-existing type 1 or 2 diabetes mellitus. Clinical and biochemical parameters were analysed in relation to obstetric and fetal outcomes. 14.2% received treatment with Neutral Protamine Hagedorn insulin and short-acting insulin analogues; 19% with premixed human insulin; 40.1% with insulin glargine and lispro, 6.2% with detemir and aspart and 20% with continuous subcutaneous insulin infusion. All 5 types of treatment achieved a reduction of the mean HbA1c during pregnancy (p = 0.01). Pre-pregnancy care was carried out for 48% of patients. We found no statistically significant differences between the different insulin therapies and the obstetric-fetal outcomes. In conclusión, the different insulin therapies used in patients with pregestational diabetes mellitus does not seem to affect obstetric-fetal outcomes.

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