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Updated: Jan 3, 2026

Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue
Published on: July 28, 2018
Lymphatic vessels in human adipose tissue
Patricia de Albuquerque Garcia Redondo1,2, Fernanda Gubert3,4, Camila Zaverucha-do-Valle4,5
1Programa de Ciências Morfológicas, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. prbioeng@gmail.com.
Abstract:
Despite being considered present in most vascularised tissues, lymphatic vessels have not been properly shown in human adipose tissue (AT). Our goal in this study is to investigate an unanswered question in AT biology, regarding lymphatic network presence in tissue parenchyma. Using human subcutaneous (S-) and visceral (V-) AT samples with whole mount staining for lymphatic specific markers and three-dimensional imaging, we showed lymphatic capillaries and larger lymphatic vessels in the human VAT. Conversely, in the human SAT, microcirculatory lymphatic vascular structures were rarely detected and no initial lymphatics were found.
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