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Risk of cerebro- and cardiovascular disease in patients with scrub typhus

Lae Young Jung1,2, Juhyung Lee2,3, Mir Jeon1

  • 1Department of Internal Medicine, Chonbuk National University, Jeonju, Republic of Korea.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|November 29, 2019
PubMed

Insights

Scrub typhus infection increases the long-term risk of cardiovascular disease, but not cerebrovascular disease. This finding highlights the importance of monitoring heart health in scrub typhus survivors.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Epidemiology

Background:

  • Scrub typhus is a bacterial infection with potential systemic effects.
  • Long-term sequelae of scrub typhus, particularly cardiovascular and cerebrovascular risks, are not well-established.

Purpose of the Study:

  • To investigate the association between scrub typhus infection and the subsequent risk of cardiovascular disease (CVD) and cerebrovascular disease (CeVD).

Main Methods:

  • Analysis of the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database.
  • Comparison of incidence rates of CVD and CeVD between scrub typhus patients and a control group.

Main Results:

  • The scrub typhus group exhibited a higher incidence rate of cardiovascular disease (14.5 vs. 9.0 per 1000 person-years).
  • No significant difference in the incidence rate of cerebrovascular disease was observed between the groups (12.0 vs. 13.3 per 1000 person-years).

Conclusions:

  • Scrub typhus infection is associated with an elevated long-term risk of developing cardiovascular disease.
  • The study suggests a need for enhanced cardiovascular monitoring in individuals with a history of scrub typhus.

Keywords:
Myocardial infarctionRepublic of KoreaScrub typhusStroke

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