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Related Experiment Video

Updated: Jan 3, 2026

Murine Model of Epicutaneously-Induced Immunomodulation

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

Microbial interactions in the atopic march.

B Nibbering¹, N D J Ubags¹

¹Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, CHUV, Lausanne, Switzerland.

Clinical and Experimental Immunology

|November 29, 2019

Summary

This summary is machine-generated.

The human body

Keywords:

allergy lung skin

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Area of Science:

Microbiology
Immunology
Allergy Research

Background:

The human body hosts diverse microbial communities (microbiota) crucial for immune system development and function.
Increasing prevalence of atopic diseases and early-life allergic sensitization highlights the need to understand contributing factors.
Immune responses in allergic conditions affecting skin, gut, and lungs may correlate with microbial shifts.

Purpose of the Study:

To review current knowledge on microbial interactions in allergic diseases.
To explore the potential role of the microbiota in the 'atopic march'.

Main Methods:

Literature review of studies on microbiota and allergic diseases.
Analysis of research linking microbial changes to immune responses in atopic conditions.

Main Results:

Microbiota significantly influences immune system maturation and function.
Microbial dysbiosis is increasingly implicated in the development and progression of allergic diseases.
Evidence suggests a connection between microbial alterations and the 'atopic march'.

Conclusions:

Microbial communities play a critical role in immune homeostasis and allergic disease pathogenesis.
Understanding these microbial interactions is key to addressing the rising incidence of allergies.
Targeting the microbiota may offer novel therapeutic strategies for allergic diseases.