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Updated: Jan 3, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Approach to Tertiary-Type β-Hydroxyl Carboxamides Through Sc(OTf)3-Catalyzed Addition of Ynamides and Ketones
Yi-Wen Liu1, Zhuo-Ya Mao1, Xiao-Di Nie1
1Institutes of Biomedical Sciences and School of Pharmacy , Fudan University , 220 Handan Road , Shanghai 200433 , China.
Abstract:
An efficient approach to access functionalized tertiary-type β-hydroxyl carboxamides has been developed through Sc(OTf)3-catalyzed addition of ynamides and substituted ketones. Water was found to be an important reaction substrate, and the solvent was not needed in this process. A broad range of substituted ynamides and ketones was well applicable to the reaction with excellent chemical selectivities. Moreover, several chiral β-hydroxyl carboxamides 3j-3r were prepared with excellent regioselectivities and outstanding diastereoselectivities.
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