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Vilazodone poisoning: a systematic review.

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Vilazodone overdose can cause severe toxicity, including seizures and serotonin syndrome, especially in children. Even small ingestions pose significant risks, necessitating medical monitoring.

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CNS and psychologicalCNS/psychologicalcomplications of poisoning respiratory supportcritical/intensive careorgan/tissue specificpharmaceuticals

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Area of Science:

  • Pharmacology
  • Toxicology
  • Clinical Medicine

Background:

  • Vilazodone is a novel antidepressant for major depressive disorder.
  • It functions as a serotonin reuptake inhibitor and 5-HT1A partial agonist.
  • Potential for rapid serotonin increase may enhance toxicity in overdose compared to SSRIs.

Purpose of the Study:

  • To systematically review medical literature on vilazodone poisoning.
  • To identify and analyze case reports and data reviews concerning vilazodone overdose.

Main Methods:

  • Systematic literature review.
  • Inclusion of peer-reviewed articles on vilazodone poisoning.
  • Analysis of case reports and poison data system reviews.

Main Results:

  • Nine articles detailing vilazodone poisoning were identified.
  • Eleven case reports, three National Poison Data System reviews, and one Toxicology Investigators Consortium review were analyzed.
  • Children frequently experienced seizures and serotonin syndrome; adults and adolescents also developed serotonin syndrome.

Conclusions:

  • Vilazodone poisoning can lead to serious clinical effects like serotonin syndrome and seizures.
  • Young children are at high risk, experiencing severe illness from small ingestions.
  • Hospital admission for children and prolonged observation for adults are recommended after vilazodone ingestion.