Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

43.1K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.1K
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

406
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
406
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

691
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
691
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

705
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
705
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

529
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
529
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.1K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting Ferroptosis to Overcome Radioresistance and Enhance Immunotherapy in Colorectal Cancer.

Cells·2026
Same author

Instability in Pentanucleotide Markers in a Subset of Microsatellite Instability-High Colorectal Cancer.

Current oncology (Toronto, Ont.)·2026
Same author

Expert Commentary on Ulcerative Colitis-Associated Neoplasia.

Diseases of the colon and rectum·2026
Same author

The Need for Individualized Decision-Making for Neoadjuvant Therapy in Advanced Colon Cancer.

JAMA surgery·2026
Same author

A history of the collaborative group of the Americas on inherited gastrointestinal cancer (CGA-IGC): 1995-2025.

Familial cancer·2026
Same author

A Critical Appraisal of Colorectal Surgery Fellowship Standardized Letters of Recommendations Using Objective Criteria.

Diseases of the colon and rectum·2026

Related Experiment Video

Updated: Jan 3, 2026

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis
08:17

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis

Published on: January 14, 2017

8.9K

Serrated Polyps and Serrated Polyposis Syndrome.

Jean H Ashburn1, Thomas P Plesec2, Matthew F Kalady1

  • 1Department of Colorectal Surgery, Sanford R. Weiss, MD, Center for Inherited Colorectal Neoplasia, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio.

Clinics in Colon and Rectal Surgery
|November 29, 2019
PubMed
Summary

Serrated polyps are key intermediate lesions in a distinct colorectal cancer pathway. Understanding these unique growths improves classification, detection, and management strategies for serrated polyposis syndrome.

Keywords:
serrated neoplasiaserrated polyposisserrated polypssessile serrated adenoma/polyp

More Related Videos

Surgical Robot-Assisted Transanal Specimen Extraction Radical Sigmoidectomy Without an Auxiliary Abdominal Incision
07:22

Surgical Robot-Assisted Transanal Specimen Extraction Radical Sigmoidectomy Without an Auxiliary Abdominal Incision

Published on: June 13, 2025

569
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

603

Related Experiment Videos

Last Updated: Jan 3, 2026

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis
08:17

Inducing Complete Polyp Regeneration from the Aboral Physa of the Starlet Sea Anemone Nematostella vectensis

Published on: January 14, 2017

8.9K
Surgical Robot-Assisted Transanal Specimen Extraction Radical Sigmoidectomy Without an Auxiliary Abdominal Incision
07:22

Surgical Robot-Assisted Transanal Specimen Extraction Radical Sigmoidectomy Without an Auxiliary Abdominal Incision

Published on: June 13, 2025

569
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

603

Area of Science:

  • Gastroenterology and Oncology
  • Molecular Pathology

Background:

  • Colorectal serrated polyps represent intermediate lesions in a distinct neoplastic pathway.
  • This serrated pathway accounts for up to 30% of colorectal cancers.
  • It is biologically distinct from the traditional adenoma-to-carcinoma sequence.

Purpose of the Study:

  • To review the current understanding of colorectal serrated polyps.
  • To discuss serrated polyposis syndrome.
  • To highlight advancements in classification, identification, and management.

Main Methods:

  • Literature review of serrated polyps and serrated polyposis syndrome.
  • Analysis of the biological distinctiveness of the serrated pathway.
  • Examination of evolving classification and management guidelines.

Main Results:

  • Serrated cancers exhibit specific molecular features: BRAF oncogene mutations, promoter hypermethylation, and microsatellite instability.
  • An improved classification system for serrated polyps has been developed.
  • Enhanced endoscopic identification techniques and tailored clinical guidelines are emerging.

Conclusions:

  • Colorectal serrated polyps are significant precursors to cancer via a unique pathway.
  • Advances in understanding have led to better diagnostic and management approaches.
  • Further research into serrated polyps and serrated polyposis syndrome is crucial.