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Probiotic Studies in Neonatal Mice Using Gavage
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Probiotics decrease the stress response and intestinal permeability of term neonates with low Apgar scores.

Jie Wu1, Juanli Zhang1, Jing Chen1

  • 1The Second Department of Neonatology, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Experimental and Therapeutic Medicine
|November 29, 2019
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Summary

Probiotics significantly reduced stress responses and improved intestinal permeability in term neonates with low Apgar scores. This led to better gastrointestinal function recovery and shorter hospital stays.

Keywords:
intestinal permeabilitylow Apgar scoreprobioticsstress responseterm neonates

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Area of Science:

  • Neonatal Medicine
  • Microbiology
  • Gastroenterology

Background:

  • Term neonates with low Apgar scores often experience heightened stress responses and compromised intestinal barrier function.
  • Intestinal permeability issues can exacerbate stress and hinder recovery in vulnerable infants.

Purpose of the Study:

  • To investigate the efficacy of probiotics in mitigating stress and improving intestinal permeability in term neonates with low Apgar scores.
  • To assess the impact of probiotics on key physiological stress markers and gastrointestinal recovery indicators.

Main Methods:

  • Retrospective analysis of 78 term neonates, divided into a control group (standard care) and an observation group (standard care + Lactobacillus Complex Capsules).
  • Measurement of corticotropin-releasing factor, cortisol, D-lactate, diamine oxidase, procalcitonin, and C-reactive protein levels.
  • Comparison of clinical outcomes including daily milk intake, length of hospital stay, and total parenteral nutrition duration.

Main Results:

  • The observation group showed statistically significant reductions in stress markers (corticotropin-releasing factor, cortisol, D-lactate, diamine oxidase, procalcitonin, C-reactive protein) compared to the control group (P<0.05).
  • Neonates receiving probiotics had significantly higher daily milk intake (16.57±2.58 ml vs. 13.26±1.87 ml).
  • The probiotic group experienced significantly shorter hospital stays (12.31±2.02 days vs. 14.86±2.58 days) and reduced total parenteral nutrition time (6.21±1.26 days vs. 8.86±1.78 days) (P<0.001).

Conclusions:

  • Probiotics administration is effective in ameliorating stress responses in term neonates with low Apgar scores.
  • Probiotics significantly improve intestinal permeability, contributing to enhanced gastrointestinal function recovery.
  • The use of probiotics in this cohort facilitates faster recovery and reduces the need for prolonged medical interventions.