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Updated: Jan 3, 2026
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An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
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Intraoperative methadone for postoperative pain management - systematic review protocol
Zhaosheng Jin1, Erica J Lin1,2, Yaohua He3
1Department of Anesthesiology, Stony Brook University Health Science Center Stony Brook, NY 11794-8480, USA.
International Journal of Physiology, Pathophysiology and Pharmacology
|November 29, 2019
Summary
Methadone, a long-acting opioid, shows promise for managing postoperative pain and reducing opioid-related side effects. This meta-analysis protocol outlines an investigation into its effectiveness for surgical pain relief.
Area of Science:
- Anesthesiology
- Pharmacology
- Pain Management
Background:
- Methadone is a long-acting opioid used for opioid withdrawal.
- It is proposed as a single-dose anesthetic adjunct for postoperative analgesia.
- Existing small studies suggest potential benefits with minimal adverse events.
Purpose of the Study:
- To conduct a meta-analysis on the postoperative analgesic efficacy of methadone.
- To evaluate the safety profile of methadone in the perioperative setting.
Main Methods:
- Protocol for a systematic literature review and meta-analysis.
- Inclusion criteria will focus on studies investigating methadone for postoperative pain.
- Data synthesis will assess analgesic outcomes and adverse events.
Main Results:
- This section will present findings from the meta-analysis once conducted.
- Anticipated results include quantitative data on pain scores and opioid consumption.
- Adverse event rates will be compared to control groups.
Conclusions:
- The meta-analysis aims to provide robust evidence on methadone's role in postoperative pain management.
- Findings will inform clinical practice regarding methadone's efficacy and safety.
- This research seeks to clarify methadone's utility as a multimodal analgesic strategy.
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