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Burden of Psychiatric Disorders among Pediatric and Young Adults with Inflammatory Bowel Disease: A Population-Based
Aravind Thavamani1, Krishna Kishore Umapathi1, Jasmine Khatana1
1Department of Pediatrics, Case Western Reserve University (Metro Health) Program, Cleveland, OH, USA.
Insights
Psychiatric disorders are 5 times more likely in pediatric and young adult patients with inflammatory bowel disease (IBD). This study highlights the need for integrated mental health services for IBD care.
Area of Science:
- Gastroenterology
- Psychiatry
- Public Health
Background:
- Inflammatory bowel disease (IBD) affects a significant population, with growing recognition of associated psychiatric comorbidities.
- Psychiatric disorders independently impact the quality of life for individuals with IBD.
Purpose of the Study:
- To determine the prevalence of psychiatric disorders in pediatric and young adult patients diagnosed with IBD.
- To analyze population-based data on the association between IBD and psychiatric conditions.
Main Methods:
- Retrospective analysis of deidentified healthcare data from over 360 US hospitals.
- Inclusion of patients aged 5-24 years with IBD (Crohn's disease or ulcerative colitis) and comparison with controls.
- Predefined identification of 10 psychiatric disorders using Systematized Nomenclature of Medicine-Clinical Terms (SNOMED CT).
Main Results:
- The study analyzed over 11.3 million patients, identifying 58,020 with IBD.
- A prevalence of 21.6% for psychiatric disorders, primarily depression and anxiety, was observed in the IBD cohort.
- IBD patients were 5 times more likely to have psychiatric disorders than controls (p<0.001), with a rising incidence trend from 2% in 2006 to 15% in 2017.
Conclusions:
- This large population-based study confirms a significantly increased prevalence of psychiatric disorders among IBD patients.
- Findings underscore the critical need to integrate psychological and mental health support into routine IBD clinical care.
- Early identification and management of mental health conditions are crucial for improving outcomes in young IBD patients.
Purpose:
There is increasing prevalence of psychiatric disorders among inflammatory bowel Disease (IBD) population. Further, presence of psychiatric disorders has been shown as an independent predictor of quality of life among patients with IBD. We intended to explore the prevalence of various psychiatric disorders among pediatric and young adult population with IBD as a population-based analysis.
Methods:
We did a retrospective case control analysis using a deidentified cloud-based database including health care data across 26 health care networks comprising of more than 360 hospitals across USA. Data collected across different hospitals were classified and stored according to Systematized Nomenclature of Medicine-Clinical Terms. We preidentified 10 psychiatric disorders and the queried the database for the presence of at least one of the ten psychiatric disorders among IBD patients between 5 and 24 years of age and compared with controls.
Results:
Total of 11,316,450 patients in the age group between 5 and 24 years and the number of patients with a diagnosis of IBD, Crohn's disease or ulcerative colitis were 58,020. The prevalence of psychiatric disorders was 21.6% among IBD mainly comprising of depression and anxiety disorder. Multiple logistic regression analysis showed, IBD is 5 times more likely associated with psychiatric disorders than controls, p<0.001). We showed a steady increasing trend in the incidence of psychiatric disorders among IBD patients (2% in 2006 to 15% in 2017).
Conclusion:
Largest population-based analysis demonstrated an increased prevalence of psychiatric disorders among IBD patients. Our study emphasizes the need for psychological and mental health services to be incorporated as a part of the routine IBD clinic.
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