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Updated: Jan 3, 2026

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum

Published on: January 22, 2019

Delayed nucleation in lipid particles.

Guy Jacoby¹, Irina Portnaya², Dganit Danino²

¹The Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Ramat Aviv, Tel Aviv 6997801, Israel. roy@tauex.tau.ac.il.

|November 29, 2019

Summary

This summary is machine-generated.

The crystallization delay in phospholipid liquid-crystalline phases is tunable, deviating from classical nucleation theory. This controllable metastability in dilauroyl-phosphatidylethanolamine (DLPE) offers new possibilities for drug delivery systems.

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Area of Science:

Materials Science
Physical Chemistry
Biophysics

Background:

Classical nucleation theory (CNT) traditionally describes metastable states in first-order phase transitions.
An increasing number of systems, particularly phospholipids, do not conform to CNT predictions.
Phospholipids, vital in drug delivery, exhibit delayed crystallization upon super-cooling, allowing exploration of dynamics.

Purpose of the Study:

To investigate the controllable behavior of the metastable liquid-crystalline phase of dilauroyl-phosphatidylethanolamine (DLPE) in multi-lamellar vesicles.
To understand the factors influencing the transition dynamics to the crystalline state.
To explore potential applications in programmable drug delivery.

Main Methods:

Experimental manipulation of dilauroyl-phosphatidylethanolamine (DLPE) in multi-lamellar vesicles.
Tuning crystallization delay by altering quenching temperature, solution salinity, and adding secondary phospholipids.
Observing bulk crystallization phenomena and deviations from classical nucleation theory.

Main Results:

Demonstrated controllable behavior of the long-lived metastable liquid-crystalline phase of DLPE.
Showcased tunable crystallization delay spanning two orders of magnitude.
Observed robust persistence of metastability, deviating significantly from CNT predictions.
Identified potential explanation in multi-lamellar vesicle resistance to crystalline domain deformations.

Conclusions:

The metastability of DLPE liquid-crystalline phases is robust and tunable, defying classical nucleation theory.
The observed deviation may stem from the structural integrity of multi-lamellar vesicles resisting nucleation.
Programmable control over phospholipid phase transitions offers significant potential for advanced drug delivery platforms.