Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservation of Protein Domains02:26

Conservation of Protein Domains

3.9K
3.9K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

13.9K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
13.9K
Conserved Binding Sites01:49

Conserved Binding Sites

5.0K
Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
5.0K
Conserved Binding Sites01:49

Conserved Binding Sites

1.9K
1.9K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.6K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.6K
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

3.6K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction.

Cell stem cell·2026
Same author

Elucidating the interaction between pyrazine flavor compounds and coffee proteins: Insights from multiscale structural and molecular dynamics simulations.

Current research in food science·2026
Same author

Angelica dahurica alleviates migraine via ameliorating neuroinflammation and oxidative stress.

Journal of ethnopharmacology·2026
Same author

Pilot Study of Gallic Acid Cream as a Potential Treatment for Plaque Psoriasis.

Journal of medicinal food·2026
Same author

STNAGNN: Data-driven Spatio-temporal Brain Connectivity beyond FC.

Proceedings of machine learning research·2026
Same author

<i>MFAP2</i> Promotes Glioblastoma Malignant Phenotypes via Autophagy-Dependent Activation of Wnt/β-Catenin Signaling.

Biomedicines·2026
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Jan 3, 2026

Author Spotlight: Optimizing Cryo-EM Analysis with CryoSieve for Enhanced Particle Selection Efficiency
06:41

Author Spotlight: Optimizing Cryo-EM Analysis with CryoSieve for Enhanced Particle Selection Efficiency

Published on: May 10, 2024

2.4K

CDD/SPARCLE: the conserved domain database in 2020.

Shennan Lu1, Jiyao Wang1, Farideh Chitsaz1

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research
|November 29, 2019
PubMed
Summary
This summary is machine-generated.

The Conserved Domain Database (CDD) provides hierarchical classifications and conserved site information for protein domains, aiding hypothesis-driven research. It offers archived annotations and live search services for diverse biological queries.

More Related Videos

Imaging Dendritic Spines in Caenorhabditis elegans
09:14

Imaging Dendritic Spines in Caenorhabditis elegans

Published on: September 27, 2021

2.7K
A Robust Single-Particle Cryo-Electron Microscopy cryo-EM Processing Workflow with cryoSPARC, RELION, and Scipion
13:43

A Robust Single-Particle Cryo-Electron Microscopy cryo-EM Processing Workflow with cryoSPARC, RELION, and Scipion

Published on: January 31, 2022

14.8K

Related Experiment Videos

Last Updated: Jan 3, 2026

Author Spotlight: Optimizing Cryo-EM Analysis with CryoSieve for Enhanced Particle Selection Efficiency
06:41

Author Spotlight: Optimizing Cryo-EM Analysis with CryoSieve for Enhanced Particle Selection Efficiency

Published on: May 10, 2024

2.4K
Imaging Dendritic Spines in Caenorhabditis elegans
09:14

Imaging Dendritic Spines in Caenorhabditis elegans

Published on: September 27, 2021

2.7K
A Robust Single-Particle Cryo-Electron Microscopy cryo-EM Processing Workflow with cryoSPARC, RELION, and Scipion
13:43

A Robust Single-Particle Cryo-Electron Microscopy cryo-EM Processing Workflow with cryoSPARC, RELION, and Scipion

Published on: January 31, 2022

14.8K

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Structural Biology

Background:

  • The Conserved Domain Database (CDD) is a publicly available resource developed by the National Library of Medicine (NLM).
  • CDD has been operational for 20 years, providing valuable data for biomolecular research.
  • Ongoing curation efforts are essential for maintaining and expanding the database.

Purpose of the Study:

  • To highlight the continued development and services of the Conserved Domain Database (CDD).
  • To emphasize CDD's role in classifying protein domain families and identifying conserved sites.
  • To showcase CDD's utility in supporting hypothesis-driven biomolecular research.

Main Methods:

  • Hierarchical classification of protein domain families.
  • Recording of conserved sites linked to molecular function.
  • Development of curated domain architectures for protein family characterization.
  • Provision of live search services for single and multiple sequence queries.
  • Availability of domain architecture definitions via SPARCLE (Subfamily Protein Architecture Labeling Engine).

Main Results:

  • CDD provides a comprehensive archive of pre-computed domain annotations.
  • Live search services facilitate queries for single proteins, nucleotides, and larger sequence sets.
  • Significant corpus of curated domain architectures has been established.
  • These architectures support the naming of bacterial proteins in RefSeq.
  • SPARCLE engine makes architecture definitions accessible.

Conclusions:

  • The Conserved Domain Database (CDD) remains a vital and evolving resource for the scientific community.
  • CDD's curated classifications and search capabilities empower biomolecular research.
  • Continued development ensures CDD's relevance in characterizing protein families and supporting data annotation.