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Updated: Jan 3, 2026
Influenza A Virus Studies in a Mouse Model of Infection
Published on: September 7, 2017
Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host
Silvio Hemmi1, Katherine R Spindler2
1Institute of Molecular Life Sciences, University of Zürich, Switzerland.
Abstract:
Small laboratory animals are powerful models for investigating in vivo viral pathogenesis of a number of viruses. For adenoviruses (AdVs), however, species-specificity poses limitations to studying human adenoviruses (HAdVs) in mice and other small laboratory animals. Thus, this review covers work on naturally occurring mouse AdVs, primarily mouse adenovirus type 1 (MAdV-1), a member of the species Murine mastadenovirus A. Molecular genetics, virus life cycle, cell and tissue tropism, interactions with the host immune response, persistence, and host genetics of susceptibility are described. A brief discussion of MAdV-2 (member of species Murine mastadenovirus B) and MAdV-3 (member of species Murine mastadenovirus C) is included. We report the use of MAdVs in the development of vectors and vaccines.
Insights
Mouse adenoviruses (MAdVs) are valuable models for studying viral diseases in vivo. This review details MAdV-1, covering its genetics, replication, host interactions, and use in developing vaccines and vectors.
Area of Science:
- Virology
- Immunology
- Genetics
Background:
- Small laboratory animals serve as crucial models for in vivo viral pathogenesis research.
- Species-specificity of human adenoviruses (HAdVs) limits their study in mice.
- Naturally occurring mouse adenoviruses (MAdVs) offer alternative models for adenovirus research.
Purpose of the Study:
- To review the molecular genetics, life cycle, and host interactions of mouse adenoviruses (MAdVs).
- To highlight the utility of MAdVs, particularly MAdV-1, in understanding viral pathogenesis.
- To discuss the application of MAdVs in the development of novel vectors and vaccines.
Main Methods:
- Literature review focusing on MAdV-1, MAdV-2, and MAdV-3.
- Analysis of studies on MAdV molecular genetics and viral life cycle.
- Examination of research on MAdV-host immune interactions and susceptibility genetics.
Main Results:
- MAdV-1, a Murine mastadenovirus A member, is extensively studied for its pathogenesis.
- Detailed descriptions of MAdV-1's genetics, tropism, immune response, persistence, and host susceptibility are provided.
- MAdVs have demonstrated potential in the development of advanced vectors and vaccines.
Conclusions:
- Mouse adenoviruses, especially MAdV-1, are powerful models for in vivo adenovirus research.
- Understanding MAdV biology facilitates insights into viral pathogenesis and host responses.
- MAdVs show promise for biotechnological applications in vaccine and vector development.
