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Related Experiment Video

Updated: Jan 3, 2026

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Published on: December 20, 2010

Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair.

Jeffrey J D Henry¹, Lawrence Delrosario², Jun Fang³

¹Department of Bioengineering, University of California, Berkeley, CA, 94720, USA.

Advanced Healthcare Materials

|November 29, 2019

Summary

Injectable human amniotic membrane matrix improves heart function after myocardial infarction (MI). This novel hydrogel reduces fibrosis and enhances cardiac regeneration, offering a promising minimally invasive therapy for heart failure.

Keywords:

amniotic membranes decellularization hydrogels myocardial infarctions

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Last Updated: Jan 3, 2026

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Fabrication of Biologically Derived Injectable Materials for Myocardial Tissue Engineering

Published on: December 20, 2010

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

Published on: September 20, 2020

Area of Science:

Biomaterials Science
Regenerative Medicine
Cardiovascular Research

Background:

Ischemic heart disease is a leading global cause of mortality.
Myocardial infarction (MI) often leads to heart failure, characterized by fibrosis and cardiac remodeling.
Injectable hydrogels offer a minimally invasive strategy for cardiac repair.

Purpose of the Study:

To develop and evaluate a novel injectable human amniotic membrane (hAM) matrix for cardiac regeneration post-MI.
To assess the therapeutic efficacy of the hAM matrix in improving cardiac function and reducing fibrosis in a rat MI model.

Main Methods:

Human amniotic membrane was isolated and engineered into a thermoresponsive, injectable hydrogel.
Ultrasound-guided injection of the hAM matrix into rat hearts post-MI.
Assessment of cardiac function (ejection fraction) and fibrosis levels.

Main Results:

The engineered hAM matrix demonstrated thermoresponsive, injectable properties.
Injection of hAM matrix significantly improved cardiac contractility (ejection fraction).
Reduced cardiac fibrosis was observed in the hAM-treated group.

Conclusions:

An injectable hAM matrix is feasible for cardiac tissue engineering.
The hAM matrix effectively attenuates degenerative changes post-MI, improving heart function.
This approach holds potential for broad applications in myocardial regeneration and tissue repair.