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Related Experiment Video

Updated: Nov 7, 2025

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

Published on: September 7, 2022

APTANI2: update of aptamer selection through sequence-structure analysis.

Jimmy Caroli¹, Mattia Forcato¹, Silvio Bicciato¹

¹Department of Life Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy.

Bioinformatics (Oxford, England)

|November 29, 2019

Summary

This summary is machine-generated.

APTANI2 enhances aptamer selection from high-throughput sequencing data by analyzing sequence-structure relationships. This improved computational tool identifies target-specific aptamers with higher accuracy and usability.

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Area of Science:

Biotechnology
Bioinformatics
Computational Biology

Background:

Systematic Evolution of Ligands by Exponential Enrichment (SELEX) generates large aptamer candidate pools.
Selecting high-affinity, target-specific aptamers requires sophisticated computational analysis of sequence and structure data.
Existing tools may lack comprehensive features for ranking and structural motif identification.

Purpose of the Study:

To introduce APTANI2, an enhanced computational tool for aptamer selection.
To improve the accuracy and efficiency of identifying target-specific aptamers from SELEX data.
To provide advanced functionalities for sequence motif and secondary structure analysis.

Main Methods:

APTANI2 integrates sequence-structure analysis for aptamer selection.
A scoring system combines frequency and structural stability of predicted aptamer secondary structures.
Modules for in-depth motif investigation and a graphical user interface enhance usability and performance.

Main Results:

APTANI2 provides an optimized approach for aptamer selection compared to its predecessor.
The tool accurately ranks aptamers and identifies key structural motifs.
Enhanced modules and a user-friendly interface improve the overall performance and usability.

Conclusions:

APTANI2 represents a significant advancement in computational aptamer discovery.
The tool facilitates more effective selection of target-specific aptamers.
APTANI2 offers improved performance and enhanced analytical capabilities for researchers.