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Canine epidermotropic cutaneous lymphoma
R Doe1, H S Zackheim, J R Hill
1University of California, San Francisco.
The American Journal of Dermatopathology
|February 1, 1988
Summary
This study details an epidermotropic cutaneous lymphoma in a dog, noting its intense invasion of skin epithelium. Further research is needed to identify the specific cell type and its implications for human lymphoma.
Area of Science:
- Veterinary Pathology
- Dermatopathology
- Oncology
Background:
- Cutaneous lymphomas are a group of cancers affecting the skin.
- Epidermotropic lymphomas are characterized by the infiltration of neoplastic lymphocytes into the epidermis.
- Understanding canine cutaneous lymphoma can provide insights into human lymphoma pathogenesis.
Observation:
- A canine neoplasm exhibited intense epidermotropism, invading follicular and apocrine gland epithelium.
- This intense epidermotropism persisted into the tumor stage.
- Compared to human mycosis fungoides, the canine lymphoma showed less convoluted cell nuclei and a less polymorphic infiltrate.
Findings:
- The lymphoid cells appeared to undergo neoplastic transformation into cells with large, pale nuclei, prominent nucleoli, and variable cytoplasm.
- The neoplasm demonstrated thorough invasion of follicular and apocrine gland epithelium.
- Distinct histologic features were observed when compared to human mycosis fungoides.
Implications:
- In situ marker studies are crucial to determine the specific cell type of this canine neoplasm.
- Clarifying the cell type could offer valuable insights into the pathogenesis of human epidermotropic lymphomas.
- This research highlights the importance of comparative pathology in understanding complex diseases.