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Updated: Jan 3, 2026

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Myths and realities of range uncertainty
1Centre for Proton Therapy, Paul Scherrer Institute, Switzerland and Department of Physics, ETH Zurich, Switzerland.
Abstract:
Range uncertainty is a much discussed topic in proton therapy. Although a very real aspect of proton therapy, its magnitude and consequences are sometimes misunderstood or overestimated. In this article, the sources and consequences of range uncertainty are reviewed, a number of myths associated with the effect discussed with the aim of putting range uncertainty into clinical context and attempting to de-bunk some of the more exaggerated claims made as to its consequences.
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