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Hypersensitivity vasculitis induced by terbutaline sulfate.

R Enat1, R Katz, M Munichor

  • 1Department of Medicine, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa.

Annals of Allergy
|October 1, 1988
PubMed
Summary

Terbutaline sulfate can cause hypersensitivity vasculitis, a rare drug reaction. A patient developed this condition, confirmed by testing, after starting this asthma medication.

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Area of Science:

  • Pharmacology
  • Immunology
  • Dermatology

Background:

  • Terbutaline sulfate is a beta-2 adrenergic agonist used for asthma and COPD.
  • Hypersensitivity vasculitis is an inflammatory condition affecting small blood vessels.

Observation:

  • A patient developed hypersensitivity vasculitis six days after initiating terbutaline sulfate therapy.
  • The reaction presented as a leukocytoclastic vasculitic rash.

Findings:

  • A causal association was established through temporal relationship, positive lymphocyte transformation test to terbutaline sulfate, and exclusion of other causes.
  • This case represents the first documented instance of leukocytoclastic vasculitis linked to terbutaline sulfate.

Implications:

  • Clinicians should consider terbutaline sulfate as a potential cause of hypersensitivity vasculitis.
  • This finding expands the known adverse drug reactions associated with terbutaline sulfate, particularly in the realm of immune-mediated vasculitis.

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