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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Skeletal Muscle Anatomy00:55

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Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
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Satellite Stem Cells and Muscular Dystrophy01:21

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
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Updated: Jan 3, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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Musculoskeletal Tumors.

Amit Singla1, David S Geller1

  • 1Department of Orthopaedic Surgery, Montefiore Medical Center, 3400 Bainbridge Avenue, 6th Floor, Bronx, NY 10467, USA.

Pediatric Clinics of North America
|November 30, 2019
PubMed
Summary
This summary is machine-generated.

Pediatric musculoskeletal tumors are usually benign, but rare malignant sarcomas require careful management. This review covers fundamental principles and recent advancements in treating bone and soft tissue tumors in children.

Keywords:
BiopsyBone tumorsMusculoskeletal tumorsPrecision medicineSarcomaSoft tissue tumorsSurgical marginTranslation research

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Area of Science:

  • Pediatric oncology
  • Musculoskeletal oncology
  • Skeletal and soft tissue tumors

Background:

  • Pediatric musculoskeletal tumors originate from bone or soft tissues.
  • Most pediatric tumors are benign, but malignant neoplasms (sarcomas) can occur.
  • Sarcomas indicate a mesenchymal origin and require specialized management.

Purpose of the Study:

  • To summarize basic principles of pediatric tumor management.
  • To review recent advances in treating bone and soft tissue tumors.
  • To provide an overview of sarcoma management in children.

Main Methods:

  • Review of fundamental principles in tumor management.
  • Summary of recent advancements in pediatric oncology.
  • Focus on soft tissue and bone sarcomas.

Main Results:

  • Pediatric musculoskeletal tumors are predominantly benign.
  • Malignant neoplasms, or sarcomas, are rare but require specific treatment protocols.
  • Effective management relies on established oncologic principles.

Conclusions:

  • Sarcoma management in pediatric patients necessitates strict adherence to established oncologic tenets.
  • Understanding both benign and malignant tumor characteristics is crucial.
  • This article provides a foundational overview and highlights current progress in the field.