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Related Experiment Videos

EULAR/ACR classification criteria for SLE.

Martin Aringer1

  • 1Division of Rheumatology, Department of Medicine III, University Medical Center and Faculty of Medicine at the TU Dresden, Fetscherstrasse 74, 10307 Dresden, Germany.

Seminars in Arthritis and Rheumatism
|November 30, 2019
PubMed
Summary
This summary is machine-generated.

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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New classification criteria for systemic lupus erythematosus (SLE) were developed by the European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR). These criteria achieve high specificity and sensitivity, improving SLE diagnosis.

Area of Science:

  • Rheumatology
  • Immunology
  • Clinical Diagnostics

Background:

  • Systemic lupus erythematosus (SLE) classification requires accurate and sensitive criteria.
  • Previous criteria, such as ACR and SLICC 2012, had limitations in specificity or sensitivity.
  • A large international project aimed to develop improved classification criteria for SLE.

Purpose of the Study:

  • To develop and validate new classification criteria for systemic lupus erythematosus (SLE).
  • To achieve high specificity comparable to ACR criteria and high sensitivity close to SLICC 2012 criteria.
  • To establish a unified classification system with weighted items and a simplified exclusion rule.

Main Methods:

  • A large, transatlantic, and worldwide project involving EULAR and ACR.
Keywords:
AutoantibodiesClassificationDiagnosisFeverSystemic lupus erythematosus

Related Experiment Videos

  • Development of new criteria with positive antinuclear antibodies (ANA) as an entry criterion.
  • Weighted items organized into domains, with a cut-off of 10 for classification and a single exclusion rule for alternative diagnoses.

    • Main Results:

    • The new EULAR/ACR criteria demonstrated a specificity of 93% and a sensitivity of 96%.
    • These results meet the project's goals of maintaining high specificity and achieving high sensitivity.
    • Class III or IV lupus nephritis alone can reach the classification cut-off of 10.

    Conclusions:

    • The new EULAR/ACR classification criteria offer a validated approach to diagnosing SLE.
    • The criteria balance specificity and sensitivity, outperforming previous standards.
    • External validation in diverse cohorts is anticipated, with potential for future international SLE research.