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Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
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Cardiovascular manifestations of people living with HIV/AIDS: Report from a hot spot in eastern India

Trinath Kumar Mishra1, Sura Kishor Mishra1, Subhasish Singh1

  • 1M.K.C.G. Medical College & Hospital, Berhampur, India.

Indian Heart Journal
|November 30, 2019
PubMed

Insights

Cardiovascular abnormalities are common in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients, particularly with lower CD4 counts and advanced disease stages. Echocardiographic findings correlate significantly with disease progression.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) are associated with increased cardiovascular risks.
  • Understanding the spectrum of cardiovascular abnormalities in HIV/AIDS patients is crucial for comprehensive patient management.

Purpose of the Study:

  • To investigate the prevalence and characteristics of cardiovascular abnormalities in HIV/AIDS patients in India.
  • To analyze the relationship between cardiovascular abnormalities, CD4+ T-cell count, and World Health Organization (WHO) disease staging.

Main Methods:

  • A comparative study involving 200 HIV/AIDS patients and 50 healthy controls.
  • Utilized blood investigations, chest X-ray, electrocardiography (ECG), and echocardiography for assessment.

Main Results:

  • Echocardiographic abnormalities were detected in 52% of HIV/AIDS patients versus 12% of controls.
  • Left ventricular diastolic dysfunction was the most frequent echocardiographic abnormality.
  • Abnormalities were significantly more prevalent in patients with CD4 counts <200/μL and advanced WHO disease stages.

Conclusions:

  • Cardiovascular abnormalities, including ECG and echocardiographic findings, were present in a significant proportion of HIV/AIDS patients (54.5% and 52%, respectively).
  • Echocardiographic findings demonstrated a significant correlation with CD4+ T-cell count and WHO disease stage, highlighting the impact of HIV/AIDS progression on cardiac health.
Abstract

Keywords:
Cardiac involvement in HIVHIV/AIDSPLHA

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