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Updated: Jan 3, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
What is the role of the microenvironment in MDS?
Laura M Calvi1, Allison J Li1, Michael W Becker1
1University of Rochester School of Medicine, Wilmot Cancer Institute, 601 Elmwood Avenue, Box 794, Rochester, NY, 14642, USA.
Abstract:
Treating myelodysplastic syndromes (MDS) remains challenging. Hematopoiesis occurs within a heterogeneous, complex and dynamic microenvironment, and a multiplicity of mutations in hematopoietic stem and progenitor cells (HSPCs) lead to MDS. But is there a role for the microenvironment? Here we review experimental and conceptual arguments that support a role for the microenvironment, provide evidence for the disruption of the microenvironment in MDS, and explore microenvironmental signals that may provide a targetable and conserved vulnerability in MDS that transcend genetic heterogeneity.
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