Related Experiment Video

Updated: Jan 3, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

8.2K

Association between multiple respiratory viral infections and pediatric intensive care unit admission among infants

P Tsou1, A Vadivelan1, M Kovvuri1

  • 1Department of Pediatrics, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|November 30, 2019
PubMed

Insights

Infants with multiple respiratory viral infections, or multiviral bronchiolitis, face higher odds of requiring pediatric intensive care unit (PICU) admission. This finding highlights the increased severity associated with co-infections in young children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Bronchiolitis is a common respiratory infection in infants.
  • The association between multiple respiratory viral infections and severe bronchiolitis requiring pediatric intensive care unit (PICU) admission remains unclear.

Purpose of the Study:

  • To determine the association between multiple respiratory viral infections and PICU admission in infants diagnosed with bronchiolitis.

Main Methods:

  • A case-control study compared 135 infants with bronchiolitis admitted to the PICU (cases) against 135 infants admitted to a general pediatric ward (controls).
  • Multiplex polymerase chain reaction (PCR) was used to detect respiratory viruses.
  • Multivariable logistic regression analysis assessed the association between multiple viral infections (≥2 strains) and PICU admission.

Main Results:

  • Infants admitted to the PICU were younger than those admitted to the general ward.
  • Multiple viral infections were more prevalent in PICU patients (23.0%) compared to general ward patients (10.4%, P<0.001).
  • Bronchiolitis with multiple viral infections was significantly associated with higher odds of PICU admission (adjusted odds ratio: 2.56, P=0.02).

Conclusions:

  • Infants experiencing multiviral bronchiolitis demonstrate increased odds of PICU admission.
  • This suggests that co-infections contribute to more severe disease requiring intensive care.
Abstract

Keywords:
BronchiolitisInfantsMultiple respiratory viralPediatric intensive care

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.8K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.7K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
667
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
1.2K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
955
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
2.9K
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
761
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
392