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Published on: March 15, 2024
Emerging Role of Ferroptosis in Acute Kidney Injury
Zhaoxin Hu1, Hao Zhang1, Shi-Kun Yang1
1Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, China.
Abstract:
Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide accumulation and polyunsaturated fatty acid consumption, and it plays essential roles in many diseases, including cancers and neurologic diseases. Recent studies have revealed an emerging role of ferroptosis in the pathophysiological processes of AKI. Here, in the present review, we summarized the most recent discoveries on the role of ferroptosis in the pathogenesis of AKI as well as its therapeutic potential in AKI.
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