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Updated: Jan 2, 2026

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LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective

Francesco Ciccarese1, Elisabetta Zulato1, Stefano Indraccolo1

  • 1Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.

Oxidative Medicine and Cellular Longevity
|November 30, 2019
PubMed

Insights

Mutations in the Liver Kinase B1 (LKB1) gene are common in lung and cervical cancers. Targeting the LKB1 pathway shows promise for cancer therapy by influencing cellular response to stress.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Inactivating mutations in the Liver Kinase B1 (LKB1) tumor suppressor gene are prevalent in non-small-cell lung cancer (NSCLC) and cervical carcinoma.
  • LKB1 plays a critical role in regulating cellular metabolism and response to oxidative stress.
  • Epigenetic regulation of LKB1 expression is observed in various tumor types, highlighting its complex role in cancer.

Purpose of the Study:

  • To review the intricate relationship between LKB1 and its downstream targets in cancer development.
  • To explore the therapeutic potential of targeting the LKB1 pathway in various malignancies.
  • To understand how LKB1 status influences cellular responses to stress-inducing agents.

Main Methods:

  • Literature review of clinical and preclinical studies.
  • Analysis of LKB1's role in cell metabolism and oxidative stress pathways.
  • Investigation of LKB1's impact on cellular response to chemotherapy and other stress-inducing drugs.

Main Results:

  • Loss of LKB1-AMPK signaling leads to sensitivity to energy depletion and impaired redox homeostasis.
  • LKB1 status influences cellular sensitivity and resistance to various therapeutic agents.
  • An improved outcome has been observed in advanced NSCLC patients treated with chemotherapy when LKB1-AMPK signaling is lost.

Conclusions:

  • The LKB1 pathway is a crucial regulator of cellular stress responses and metabolism in cancer.
  • Targeting the LKB1 pathway represents a promising therapeutic strategy for LKB1-mutated cancers.
  • Understanding LKB1's role is key to developing effective treatments for NSCLC and other malignancies.

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