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Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab

Hana S Alahmari1,2, Nasser Y Alhowaish2, Mohammed A Omair2

  • 1Rheumatology Unit, Department of Medicine, King Khalid University, Abha, Saudi Arabia.

Case Reports in Rheumatology
|November 30, 2019
PubMed

Rituximab (RTX) is a chimeric B-cell-depleting monoclonal antibody against CD-20 positive cells that has been approved for the induction and maintenance of granulomatosis with polyangiitis (GPA). Reports have identified RTX to cause drug-related psoriasis. Many theories of underlying pathways have been proposed. However, further workup around the mechanism and treatment is required. Here, we present a 38-year-old woman known to have GPA that developed drug-related psoriasis that was successfully treated with treatment discontinuation and starting adalimumab along with a literature review.

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