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Modulation of Multiple Signaling Pathways of the Plant-Derived Natural Products in Cancer

Li-Rui Sun1, Wei Zhou1, Hong-Mei Zhang1

  • 1Department of Pharmacy, The First Hospital of Jilin University, Changchun, China.

Frontiers in Oncology
|November 30, 2019
PubMed

Insights

Natural compounds like polyphenols and alkaloids are effective anticancer agents. This review details how these compounds regulate key cancer pathways, aiding drug discovery.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Natural Products Chemistry

Background:

  • Plant-derived natural compounds show significant anticancer potential.
  • Existing research extensively documents targets of these agents.
  • Understanding their mechanisms is crucial for developing new therapies.

Purpose of the Study:

  • To review signaling pathways in cancer (apoptosis, proliferation, invasion, metastasis).
  • To analyze how major classes of natural compounds (polyphenols, alkaloids, saponins, polysaccharides) regulate these pathways.
  • To explore structure-activity relationships for drug discovery.

Main Methods:

  • Literature review of scientific studies.
  • Analysis of signaling pathways targeted by natural compounds.
  • Categorization of compounds by chemical class and targeted pathways.

Main Results:

  • Alkaloids predominantly impact apoptosis pathways.
  • Polysaccharides primarily target proliferation, invasion, and metastasis pathways.
  • Flavonoids and saponins exhibit broader effects, influencing multiple pathways.

Conclusions:

  • Natural compounds offer diverse mechanisms for anticancer therapy.
  • Specific compound classes interact with distinct cancer signaling pathways.
  • Elucidating compound structure-pathway associations is key for novel anticancer drug development.
Keywords:
alkaloidcancernatural active compoundspolyphenolpolysaccharidesaponinsignaling pathway

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