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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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Incipient Diabetes Treated with Long-Term Classical Prescription.

Xiuxiu Wei1,2, Jiaxing Tian1, Xinmiao Wang1

  • 1Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Journal of Diabetes Research
|November 30, 2019
PubMed
Summary
This summary is machine-generated.

Traditional Chinese Medicine (TCM) offers a potential long-term solution for managing diabetes mellitus (DM). A 10-year case study shows continuous TCM treatment effectively controlled blood glucose and prevented complications.

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Area of Science:

  • Integrative Medicine
  • Endocrinology
  • Pharmacology

Background:

  • Diabetes mellitus (DM) is a progressive, irreversible disease characterized by declining beta-cell function.
  • Current treatments for DM cannot reverse disease progression.
  • Traditional Chinese Medicine (TCM) shows promise in DM management, but long-term studies are scarce.

Observation:

  • A 64-year-old male with uncontrolled diabetes (HbA1c 14.2%) presented with hyperglycemia and early diabetic nephropathy (UAER 32.9 μg/min).
  • The patient received continuous classical TCM prescription treatment for 10 years.
  • Initial treatment led to significant blood glucose reduction and symptom improvement within 3 months.

Findings:

  • Long-term TCM treatment normalized urinary albumin excretion rate (UAER) and resolved blurred vision.
  • The patient maintained stable blood glucose levels and normal UAER over the 10-year period.
  • TCM treatment demonstrated efficacy in preventing and managing diabetic complications.

Implications:

  • This case provides a reference for long-term diabetes management using TCM.
  • TCM may offer a viable alternative for controlling blood glucose and protecting islet function.
  • Further research into TCM for diabetes is warranted to explore its potential as an alternative therapy.