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Updated: Jan 2, 2026
Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
Aggregation-induced emission-active Au nanoclusters for ratiometric sensing and bioimaging of highly reactive oxygen
Xiang Ran1, Zhenzhen Wang2, Fang Pu2
1State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. pufang@ciac.ac.cn jren@ciac.ac.cn xqu@ciac.ac.cn and School of Pharmacy, Anhui Medical University, Hefei, 230031, China.
Abstract:
We prepared a nanoprobe through self-assembly of gold nanoclusters (AuNCs) and using FITC-modified hyaluronic acid (HA) for ratiometric sensing of highly reactive oxygen species (hROS). Taking advantage of the aggregation-induced emission (AIE) properties of the self-assembled AuNCs, hROS-responsive cleavage of HA, and the ratiometric signal change of dual-emission, the nanoprobe exhibited excellent performance in imaging hROS in living cells.
