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Related Concept Videos

Aging01:26

Aging

543
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
543
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

158
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
158
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

189
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
189
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

175
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
175
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

191
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
191

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Related Experiment Video

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Aging: therapeutics for a healthy future.

Robert Hodgson1, Brian K Kennedy2, Eliezer Masliah3

  • 1Charles River Laboratories, Wilmington, MA, United States; CNS Biology, Takeda, San Diego, CA, United States.

Neuroscience and Biobehavioral Reviews
|November 30, 2019
PubMed
Summary
This summary is machine-generated.

As lifespans increase, age-related disorders pose a significant challenge. Developing effective therapeutics for aging requires defining aging as a target, improving preclinical models, and ensuring successful clinical translation.

Keywords:
AgingHealthspanLongevityNeurodegenerationReview

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Area of Science:

  • Gerontology and Pharmaceutical Science
  • Neuroscience and Aging Research

Background:

  • Increased lifespan has led to a rise in age-related disorders, posing a societal burden.
  • Neurological conditions like Alzheimer's disease highlight the need for aging therapeutics.
  • Pathological aging encompasses a wide spectrum of neurological and peripheral conditions.

Purpose of the Study:

  • To address the critical unmet need for therapeutics targeting aging and age-related disorders.
  • To identify fundamental scientific and translational challenges in developing anti-aging treatments.
  • To guide the field by outlining key issues and potential roadblocks in aging therapeutics research.

Main Methods:

  • Defining aging as a specific therapeutic target.
  • Developing and validating preclinical models for aging research.
  • Investigating strategies for effective translation of preclinical findings to human clinical trials.

Main Results:

  • The development of therapeutics for aging is a largely unexplored but crucial area.
  • Significant scientific questions remain regarding the definition, modeling, and translation of aging therapies.
  • Financial, regulatory, and clinical hurdles must be overcome to bring novel aging therapeutics to market.

Conclusions:

  • Addressing the challenge of aging disorders requires a multi-faceted approach with diverse perspectives and collaborations.
  • Overcoming current roadblocks is essential to meet the urgent need for effective aging and age-related disorder treatments.
  • Successful development of aging therapeutics presents a significant opportunity to improve health in an aging global population.