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Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Related Experiment Video

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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Multifunctional calcium phosphate based coatings on titanium implants with integrated trace elements.

C Wolf-Brandstetter1, R Beutner, R Hess

  • 1Max Bergmann Center of Biomaterials, Technische Universität Dresden, Dresden, Germany.

Biomedical Materials (Bristol, England)
|November 30, 2019
PubMed
Summary
This summary is machine-generated.

New titanium implant coatings incorporate copper and zinc to combat infections and enhance bone growth. These multifunctional coatings show promising results for improved implant performance and reduced bacterial adhesion.

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Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Nanotechnology

Background:

  • Titanium implants traditionally focus on osseointegration for bone restoration.
  • Increasing antibiotic resistance necessitates implants with antimicrobial properties to prevent infections.
  • Calcium phosphate coatings offer a versatile platform for incorporating trace elements.

Purpose of the Study:

  • To develop multifunctional calcium phosphate coatings for titanium implants by integrating copper and zinc.
  • To evaluate the antimicrobial efficacy, osteogenic potential, and angiogenic properties of these enhanced coatings.
  • To assess the biocompatibility and cell response to the co-deposited elements.

Main Methods:

  • Electrochemical deposition of copper and zinc onto calcium phosphate coatings.
  • Quantification of deposited copper and zinc using appropriate analytical techniques.
  • In vitro assessment of ion release in simulated body fluid and protein-containing solutions.
  • Evaluation of cell adhesion, proliferation, and cytotoxicity of human mesenchymal stromal cells.
  • Antimicrobial testing against E. coli to determine bacterial adhesion reduction.

Main Results:

  • Co-deposition of copper and zinc was achieved, with specific quantities deposited per surface area.
  • Ion release profiles varied, with copper showing a burst release and zinc a continuous release.
  • Zinc enhanced human mesenchymal stromal cell adhesion and growth in a dose-dependent manner.
  • Cytotoxic effects of copper were observed but partially mitigated by the presence of zinc.
  • Coatings with both copper and zinc significantly reduced bacterial adhesion, with optimal results for high zinc and intermediate copper content.

Conclusions:

  • Multifunctional coatings with co-deposited copper and zinc offer enhanced antimicrobial and osteogenic properties for titanium implants.
  • The combination of zinc and copper presents a promising strategy to address implant-associated infections and promote bone healing.
  • Careful control of copper and zinc concentrations is crucial to balance therapeutic benefits and potential cytotoxicity.