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Related Experiment Video

Updated: Jan 2, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

Synthetic Strategies for Dinucleotides Synthesis.

Lucie Appy¹, Crystalle Chardet¹, Suzanne Peyrottes¹

¹Nucleosides & Phosphorylated Effectors, Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, Université de Montpellier, ENSCM, Campus Triolet, cc 1705, Place Eugène Bataillon, CEDEX 5, 34095 Montpellier, France.

Molecules (Basel, Switzerland)

|December 1, 2019

Summary

Dinucleoside 5

Keywords:

denufosol dinucleotides diquafosol dry eye syndrome mechanochemistry organophosphorus chemistry phosphorylation

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Published on: July 28, 2017

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Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Area of Science:

Biochemistry and Organic Chemistry
Focus on nucleotide derivatives and their synthesis.

Background:

Dinucleoside 5',5'-polyphosphates (DNPs) are vital endogenous molecules.
They regulate critical biological processes including cell proliferation and neurotransmission.

Purpose of the Study:

To review established and novel synthetic pathways for dinucleoside 5',5'-polyphosphates.
Highlighting methods for pharmacologically relevant DNP preparation.

Main Methods:

Overview of enzymatic and chemical synthesis strategies.
Discussion of solution-phase, solid-support, and green chemistry approaches.

Main Results:

Comprehensive summary of diverse DNP synthesis methodologies.
Emphasis on recent advancements and green chemistry alternatives.

Conclusions:

Multiple synthetic routes exist for DNPs, catering to various needs.
Emerging green chemistry methods offer sustainable and efficient alternatives for DNP synthesis.