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Related Experiment Videos

Marked hyperprolactinemia in subclinical hypothyroidism.

K E Olive1, J V Hennessey

  • 1Department of Medicine, US Air Force Medical Center, Wright-Patterson Air Force Base, Ohio.

Archives of Internal Medicine
|October 1, 1988
PubMed
Summary

Marked hyperprolactinemia can occur in subclinical hypothyroidism, even without overt symptoms. This case highlights a significant prolactin elevation that resolved with thyroid hormone replacement therapy.

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Area of Science:

  • Endocrinology
  • Reproductive Medicine

Background:

  • Hyperprolactinemia is frequently observed in patients with overt primary hypothyroidism.
  • Significant elevation of serum prolactin in subclinical hypothyroidism is uncommon and rarely reported.

Observation:

  • A 45-year-old woman presented with carpal tunnel syndrome.
  • She exhibited minimally elevated thyrotropin (TSH) with normal thyroxine (T4) levels.
  • Thyrotropin-releasing hormone (TRH) stimulation testing indicated primary hypothyroidism.

Findings:

  • The patient had an unstimulated prolactin level of 187 micrograms/L.
  • Prolactin levels normalized after initiating levothyroxine therapy.
  • Visual field testing and pituitary CT scan ruled out other causes like pituitary macroadenoma.

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Implications:

  • This case suggests that significant hyperprolactinemia can manifest in subclinical hypothyroidism.
  • It underscores the importance of assessing prolactin levels in subclinical hypothyroidism.
  • Levothyroxine therapy may effectively manage hyperprolactinemia associated with subclinical hypothyroidism.