Prognostic impact of abdominal lymph node involvement in diffuse large B-cell lymphoma
Maysaa Abdulla1, Priscilla Guglielmo2,3, Peter Hollander1
1Clinical and Experimental Pathology, Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Uppsala, Sweden.
European Journal of Haematology
|December 1, 2019
Summary
Abdominal nodal involvement in diffuse large B-cell lymphoma (DLBCL) indicates a poorer prognosis. Patients with abdominal disease showed more aggressive clinical and biological features, highlighting the significance of nodal site in DLBCL outcomes.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- The prognostic impact of nodal involvement site in diffuse large B-cell lymphoma (DLBCL) remains largely uncharacterized.
- Understanding these factors is crucial for refining prognostication and treatment strategies in DLBCL.
Purpose of the Study:
- To investigate the prognostic significance of abdominal nodal involvement in DLBCL.
- To correlate abdominal nodal disease with tumor markers and clinical characteristics.
Main Methods:
- Retrospective analysis of 249 DLBCL patients.
- Abdominal and thoracic contrast-enhanced CT scans to identify pathologically enlarged abdominal lymph nodes.
- Histopathological biopsy confirmation of DLBCL in abdominal lymph nodes for a subset of patients.
Main Results:
- Abdominal nodal disease was associated with inferior lymphoma-specific survival (P=.04).
- Patients with abdominal involvement presented with higher age-adjusted IPI, elevated lactate dehydrogenase, advanced stage, bulky disease, B symptoms, and MYC/BCL2 double expression.
- Histopathological confirmation of abdominal nodal involvement correlated with the worst outcomes.
Conclusions:
- Abdominal nodal disease in DLBCL signifies a more aggressive disease behavior.
- Nodal site involvement is an important prognostic factor in DLBCL, influencing clinical and biological characteristics.
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